MED12 mutations in uterine fibroids-their relationship to cytogenetic subgroups
نویسندگان
چکیده
منابع مشابه
Mediator Complex Subunit 12 Gene Polymorphisms in Uterine Fibroids and Breast Fibroadenomas in Senegalese Women
Mediator complex subunit 12 (MED12) is a part of the mediator complex, which is believed to regulate transcription. MED12 is mutated at high frequency and with different mutation frequencies in uterine fibroids and breast fibroadenomas of different populations. This study aimed to analyze MED12 mutations in Senegalese population. MED12 was sequenced in the tumoral tissues and blood samples of S...
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1Department of Obstetrics and Gynaecology, The University of the West Indies, Kingston 7 Mona, Jamaica 2Department of Obstetrics and Gynecology, Barking, Havering and Redbridge University Hospital, Queens Hospital, Romford, Essex RM7 0AG, UK 3The University of the West Indies, Mount Hope, St. Augustine, Trinidad and Tobago 4Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
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Copyright © 2013 Massachusetts Medical Society Uterine fibroids (leiomyomas) represent the most common tumor in women. These lesions disrupt the functions of the uterus and cause excessive uterine bleeding, anemia, defective implantation of an embryo, recurrent pregnancy loss, preterm labor, obstruction of labor, pelvic discomfort, and urinary incontinence and may mimic or mask malignant tumors...
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Uterine fibroids are the commonest benign tumours of women and affect all races with a cumulative lifetime risk of around 70%. Despite their high prevalence and the heavy economic burden of treatment, fibroids have received remarkably little attention compared to common female malignant tumours. This article reviews recent progress in understanding the biological nature of fibroids, their life ...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2012
ISSN: 0020-7136
DOI: 10.1002/ijc.27424